Binding of anti-apoptotic Bcl-2 with different BH3 peptides : a molecular dynamics study

In this work, molecular dynamics simulation and free energy calculations are utilized to study how different BH3 peptides originating from Bax, Bim, Bik and Noxa interact with Bcl-2, one of the main members of anti-apoptotic proteins. The effects of peptide length, sequence and helical content on th...

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Bibliographic Details
Main Authors: Zhang, Dawei, Liu, Huihui, Cui, Jinglan
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2018
Subjects:
Online Access:https://hdl.handle.net/10356/87743
http://hdl.handle.net/10220/45473