Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial effi...

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Bibliographic Details
Main Authors: Parmar, Anish, Lakshminarayanan, Rajamani, Iyer, Abhishek, Mayandi, Venkatesh, Goh, Eunice Tze Leng, Lloyd, Daniel G., Chalasani, Madhavi Latha Somaraju, Verma, Navin Kumar, Prior, Stephen H., Beuerman, Roger W., Madder, Annemieke, Taylor, Edward J., Singh, Ishwar
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2018
Subjects:
Bacterial Infection
Teixobactin
Online Access:https://hdl.handle.net/10356/88754
http://hdl.handle.net/10220/44693

Internet

https://hdl.handle.net/10356/88754
http://hdl.handle.net/10220/44693

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