How RNA catalyzes cyclization
The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction.
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/89213 http://hdl.handle.net/10220/44839 |
| _version_ | 1811682023049265152 |
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| author | Zhong, Zhensheng Chen, Gang |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Zhong, Zhensheng Chen, Gang |
| author_sort | Zhong, Zhensheng |
| collection | NTU |
| description | The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction. |
| first_indexed | 2024-10-01T03:50:14Z |
| format | Journal Article |
| id | ntu-10356/89213 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:50:14Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/892132023-02-28T19:35:51Z How RNA catalyzes cyclization Zhong, Zhensheng Chen, Gang School of Physical and Mathematical Sciences Nucleic Acids RNA The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction. MOE (Min. of Education, S’pore) Accepted version 2018-05-18T07:54:46Z 2019-12-06T17:20:22Z 2018-05-18T07:54:46Z 2019-12-06T17:20:22Z 2015 Journal Article Zhong, Z., & Chen, G. (2015). How RNA catalyzes cyclization. Nature Chemical Biology, 11, 830-831. 1552-4450 https://hdl.handle.net/10356/89213 http://hdl.handle.net/10220/44839 10.1038/nchembio.1928 en Nature Chemical Biology © 2015 Nature America, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature Chemical Biology, Nature America, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at [http://dx.doi.org/10.1038/nchembio.1928]. 5 p. application/pdf |
| spellingShingle | Nucleic Acids RNA Zhong, Zhensheng Chen, Gang How RNA catalyzes cyclization |
| title | How RNA catalyzes cyclization |
| title_full | How RNA catalyzes cyclization |
| title_fullStr | How RNA catalyzes cyclization |
| title_full_unstemmed | How RNA catalyzes cyclization |
| title_short | How RNA catalyzes cyclization |
| title_sort | how rna catalyzes cyclization |
| topic | Nucleic Acids RNA |
| url | https://hdl.handle.net/10356/89213 http://hdl.handle.net/10220/44839 |
| work_keys_str_mv | AT zhongzhensheng howrnacatalyzescyclization AT chengang howrnacatalyzescyclization |