Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes
Two platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt complexes a significantly high stabilizing ability on both DNA and RNA G-quadruplex...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89489 http://hdl.handle.net/10220/44940 |
| _version_ | 1826116198849314816 |
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| author | He, Lei Meng, Zhenyu Xie, Yi-qun Chen, Xiang Li, Tianhu Shao, Fangwei |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences He, Lei Meng, Zhenyu Xie, Yi-qun Chen, Xiang Li, Tianhu Shao, Fangwei |
| author_sort | He, Lei |
| collection | NTU |
| description | Two platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt complexes a significantly high stabilizing ability on both DNA and RNA G-quadruplexes. Further extending alkyl tail from aromatic coordination core enabled the complexes to distinguish GQ sequence based upon the topological folding structures and enhanced the selectivity of the complex against duplex DNA. This study paved the way to develop Pt complexes as GQ stabilizers for specific folding topology and the applications to disease and/or personalized anticancer medicine/therapy. |
| first_indexed | 2024-10-01T04:07:25Z |
| format | Journal Article |
| id | ntu-10356/89489 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:07:25Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/894892023-02-28T19:36:34Z Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes He, Lei Meng, Zhenyu Xie, Yi-qun Chen, Xiang Li, Tianhu Shao, Fangwei School of Physical and Mathematical Sciences Pt Complex G-quadruplex Two platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt complexes a significantly high stabilizing ability on both DNA and RNA G-quadruplexes. Further extending alkyl tail from aromatic coordination core enabled the complexes to distinguish GQ sequence based upon the topological folding structures and enhanced the selectivity of the complex against duplex DNA. This study paved the way to develop Pt complexes as GQ stabilizers for specific folding topology and the applications to disease and/or personalized anticancer medicine/therapy. MOE (Min. of Education, S’pore) Accepted version 2018-06-04T03:20:52Z 2019-12-06T17:26:51Z 2018-06-04T03:20:52Z 2019-12-06T17:26:51Z 2017 Journal Article He, L., Meng, Z., Xie, Y.-q., Chen, X., Li, T., & Shao, F. (2017). Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes. Journal of Inorganic Biochemistry, 166, 135-140. 0162-0134 https://hdl.handle.net/10356/89489 http://hdl.handle.net/10220/44940 10.1016/j.jinorgbio.2016.11.011 en Journal of Inorganic Biochemistry © 2016 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Inorganic Biochemistry, Elsevier Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.jinorgbio.2016.11.011]. 30 p. application/pdf |
| spellingShingle | Pt Complex G-quadruplex He, Lei Meng, Zhenyu Xie, Yi-qun Chen, Xiang Li, Tianhu Shao, Fangwei Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes |
| title | Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes |
| title_full | Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes |
| title_fullStr | Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes |
| title_full_unstemmed | Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes |
| title_short | Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes |
| title_sort | aza bridged bisphenanthrolinyl pt ii complexes efficient stabilization and topological selectivity on telomeric g quadruplexes |
| topic | Pt Complex G-quadruplex |
| url | https://hdl.handle.net/10356/89489 http://hdl.handle.net/10220/44940 |
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