Evidence for allosteric effects on p53 oligomerization induced by phosphorylation

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation

p53 is a tetrameric protein with a thermodynamically unstable deoxyribonucleic acid (DNA)‐binding domain flanked by intrinsically disordered regulatory domains that control its activity. The unstable and disordered segments of p53 allow high flexibility as it interacts with binding partners and perm...

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Bibliographic Details
Main Authors: Muller, Petr, Chan, Juliana M., Simoncik, Oliver, Fojta, Miroslav, Lane, David P., Hupp, Ted, Vojtesek, Borivoj
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2019
Subjects:
DRNTU::Science::Chemistry
Protein
Oligomerization
Online Access:https://hdl.handle.net/10356/89905
http://hdl.handle.net/10220/47748

Internet

https://hdl.handle.net/10356/89905
http://hdl.handle.net/10220/47748

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