Cobalt-catalyzed C(sp2)–H/C(sp3)–H coupling via directed C–H activation and 1,5-hydrogen atom transfer

A cobalt-catalyzed C(sp2)–H/C(sp3)–H coupling reaction between an aryl imine and a 2-bromobenzyl-protected secondary amine is reported. Promoted by a combination of a cobalt–N-heterocyclic carbene catalyst and a Grignard reagent, the reaction allows for the introduction of α-aminoalkyl groups into t...

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Bibliographic Details
Main Authors: Sun, Qiao, Yoshikai, Naohiko
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/90289
http://hdl.handle.net/10220/48486