A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

LSD1 and LSD2 are homologous histone demethylases with opposite biological outcomes related to chromatin silencing and transcription elongation, respectively. Unlike LSD1, LSD2 nucleosome-demethylase activity relies on a specific linker peptide from the multidomain protein NPAC. We used single-parti...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Marabelli, Chiara, Marrocco, Biagina, Pilotto, Simona, Chittori, Sagar, Picaud, Sarah, Marchese, Sara, Ciossani, Giuseppe, Forneris, Federico, Filippakopoulos, Panagis, Schoehn, Guy, Rhodes, Daniela, Subramaniam, Sriram, Mattevi, Andrea
Rannpháirtithe: School of Biological Sciences
Formáid: Journal Article
Teanga:English
Foilsithe / Cruthaithe: 2019
Ábhair:
Histone Demethylation
Cryoelectron Microscopy
DRNTU::Science::Biological sciences
Rochtain ar líne:https://hdl.handle.net/10356/93135
http://hdl.handle.net/10220/48524

Ar líne

https://hdl.handle.net/10356/93135
http://hdl.handle.net/10220/48524

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