Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores
Cost effective, uniform-size multiparticulate formulations of the chemotherapeutic agent 5-fluorouracil (5-FU) loaded in natural Lycopodium clavatum spores were developed by three different encapsulation techniques: passive, compression and vacuum loading. The surface morphology, and micromeritic pr...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/93147 http://hdl.handle.net/10220/40599 |
| _version_ | 1811686373075189760 |
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| author | Mundargi, Raghavendra C. Tan, Ee-Lin Seo, Jeongeun Cho, Nam-Joon |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Mundargi, Raghavendra C. Tan, Ee-Lin Seo, Jeongeun Cho, Nam-Joon |
| author_sort | Mundargi, Raghavendra C. |
| collection | NTU |
| description | Cost effective, uniform-size multiparticulate formulations of the chemotherapeutic agent 5-fluorouracil (5-FU) loaded in natural Lycopodium clavatum spores were developed by three different encapsulation techniques: passive, compression and vacuum loading. The surface morphology, and micromeritic properties of 5-FU spore formulations were characterized by scanning electron microscopy and dynamic image particle analysis, respectively. The encapsulation efficiency of spores by vacuum-assisted loading was higher (49%) compared to passive and compression loading techniques. The vacuum-loaded formulation was selected for further development with a Eudragit RS 100 (EUD) coating that enabled controlled 5-FU release in simulated gastric (pH 1.2) and intestinal (pH 7.4) conditions. The surface morphology analysis after EUD coating at two different EUD concentrations (2.5% w/v and 10% w/v) indicates that a thin, conformal layer of EUD was deposited on the spore surface. The in-vitro release of 5-FU from coated spores exhibited a slower release profile compared to uncoated spores, and was extended for up to 30 h in simulated gastrointestinal conditions. Collectively, the findings demonstrate that EUD coated 5-FU loaded natural L. clavatum spores provide a controlled release formulation that would aid treatment options against gastrointestinal cancer and other related maladies. |
| first_indexed | 2024-10-01T04:59:23Z |
| format | Journal Article |
| id | ntu-10356/93147 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:59:23Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/931472020-06-01T10:01:58Z Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores Mundargi, Raghavendra C. Tan, Ee-Lin Seo, Jeongeun Cho, Nam-Joon School of Chemical and Biomedical Engineering School of Materials Science & Engineering Centre for Biomimetic Sensor Science Lycopodium clavatum Spores Microencapsulation 5-Fluorouracil Controlled release Cost effective, uniform-size multiparticulate formulations of the chemotherapeutic agent 5-fluorouracil (5-FU) loaded in natural Lycopodium clavatum spores were developed by three different encapsulation techniques: passive, compression and vacuum loading. The surface morphology, and micromeritic properties of 5-FU spore formulations were characterized by scanning electron microscopy and dynamic image particle analysis, respectively. The encapsulation efficiency of spores by vacuum-assisted loading was higher (49%) compared to passive and compression loading techniques. The vacuum-loaded formulation was selected for further development with a Eudragit RS 100 (EUD) coating that enabled controlled 5-FU release in simulated gastric (pH 1.2) and intestinal (pH 7.4) conditions. The surface morphology analysis after EUD coating at two different EUD concentrations (2.5% w/v and 10% w/v) indicates that a thin, conformal layer of EUD was deposited on the spore surface. The in-vitro release of 5-FU from coated spores exhibited a slower release profile compared to uncoated spores, and was extended for up to 30 h in simulated gastrointestinal conditions. Collectively, the findings demonstrate that EUD coated 5-FU loaded natural L. clavatum spores provide a controlled release formulation that would aid treatment options against gastrointestinal cancer and other related maladies. NRF (Natl Research Foundation, S’pore) NMRC (Natl Medical Research Council, S’pore) 2016-06-02T03:38:02Z 2019-12-06T18:34:43Z 2016-06-02T03:38:02Z 2019-12-06T18:34:43Z 2016 2016 Journal Article Mundargi, R. C., Tan, E.-L., Seo, J., & Cho, N.-J. (2016). Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores. Journal of Industrial and Engineering Chemistry, 36, 102-108. 1226-086X https://hdl.handle.net/10356/93147 http://hdl.handle.net/10220/40599 10.1016/j.jiec.2016.01.022 192646 en Journal of Industrial And Engineering Chemistry © 2016 The Korean Society of Industrial and Engineering Chemistry. |
| spellingShingle | Lycopodium clavatum Spores Microencapsulation 5-Fluorouracil Controlled release Mundargi, Raghavendra C. Tan, Ee-Lin Seo, Jeongeun Cho, Nam-Joon Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores |
| title | Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores |
| title_full | Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores |
| title_fullStr | Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores |
| title_full_unstemmed | Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores |
| title_short | Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores |
| title_sort | encapsulation and controlled release formulations of 5 fluorouracil from natural lycopodium clavatum spores |
| topic | Lycopodium clavatum Spores Microencapsulation 5-Fluorouracil Controlled release |
| url | https://hdl.handle.net/10356/93147 http://hdl.handle.net/10220/40599 |
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