X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2). The structures consist of two central, primarily hydrophobic α-helices, which are surrounded by amphipathic helices. A...

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Bibliographic Details
Main Authors: Yoon, Ho Sup, Sattler, Michael, Muchmore, Steven W., Liang, Heng, Meadows, Robert P., Harlan, John E., Nettesheim, David G., Chang, Brian S., Thompson, Craig B., Wong, Sui-Lam, Ng, Shi-Chung, Fesik, Stephen W.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2012
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/95496
http://hdl.handle.net/10220/8302

Internet

https://hdl.handle.net/10356/95496
http://hdl.handle.net/10220/8302

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