The molecular basis of distinct aggregation pathways of islet amyloid polypeptide

The molecular basis of distinct aggregation pathways of islet amyloid polypeptide

Abnormal aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils is a hallmark of type 2 diabetes. In this study, we investigated the initial oligomerization and subsequent addition of monomers to growing aggregates of human IAPP at the residue-specific level using NMR, atomic force mic...

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Bibliographic Details
Main Authors: Chan-Park, Mary B., Wei, Lei, Jiang, Ping, Xu, Weixin, Li, Hai, Zhang, Hua, Yan, Liang Yu, Liu, Xue-Wei, Tang, Kai, Mu, Yuguang, Pervushin, Konstantin
Other Authors: School of Materials Science & Engineering
Format: Journal Article
Language:English
Published: 2012
Subjects:
DRNTU::Science::Biological sciences::Biochemistry
Online Access:https://hdl.handle.net/10356/95683
http://hdl.handle.net/10220/8323

Internet

https://hdl.handle.net/10356/95683
http://hdl.handle.net/10220/8323

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