Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using C 1 -1,1′-bisisoquinoline-based chiral ligands
New highly constrained chiral C1-1,10-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/96144 http://hdl.handle.net/10220/11770 |
| _version_ | 1811688025423347712 |
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| author | Judeh, Zaher M. A. Qi, Gao |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Judeh, Zaher M. A. Qi, Gao |
| author_sort | Judeh, Zaher M. A. |
| collection | NTU |
| description | New highly constrained chiral C1-1,10-bisisoquinoline ligands were examined in the
enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone.
The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric
excess (up to 35%). |
| first_indexed | 2024-10-01T05:25:39Z |
| format | Journal Article |
| id | ntu-10356/96144 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:25:39Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/961442020-03-07T11:35:30Z Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using C 1 -1,1′-bisisoquinoline-based chiral ligands Judeh, Zaher M. A. Qi, Gao School of Chemical and Biomedical Engineering New highly constrained chiral C1-1,10-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%). 2013-07-17T07:26:43Z 2019-12-06T19:26:18Z 2013-07-17T07:26:43Z 2019-12-06T19:26:18Z 2012 2012 Journal Article Qi, G., & Judeh, Z. M. A. (2012). Catalytic Enantioselective Conjugate Addition of Grignard Reagents to Cyclic Enones Using C 1 -1,1′-Bisisoquinoline-Based Chiral Ligands. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry, 42(11), 1585-1592. https://hdl.handle.net/10356/96144 http://hdl.handle.net/10220/11770 10.1080/00397911.2010.541969 en Synthetic communications: an international journal for rapid communication of synthetic organic chemistry © 2012 Taylor & Francis Group, LLC. |
| spellingShingle | Judeh, Zaher M. A. Qi, Gao Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using C 1 -1,1′-bisisoquinoline-based chiral ligands |
| title | Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using
C
1
-1,1′-bisisoquinoline-based chiral ligands |
| title_full | Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using
C
1
-1,1′-bisisoquinoline-based chiral ligands |
| title_fullStr | Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using
C
1
-1,1′-bisisoquinoline-based chiral ligands |
| title_full_unstemmed | Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using
C
1
-1,1′-bisisoquinoline-based chiral ligands |
| title_short | Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using
C
1
-1,1′-bisisoquinoline-based chiral ligands |
| title_sort | catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using c 1 1 1 bisisoquinoline based chiral ligands |
| url | https://hdl.handle.net/10356/96144 http://hdl.handle.net/10220/11770 |
| work_keys_str_mv | AT judehzaherma catalyticenantioselectiveconjugateadditionofgrignardreagentstocyclicenonesusingc111bisisoquinolinebasedchiralligands AT qigao catalyticenantioselectiveconjugateadditionofgrignardreagentstocyclicenonesusingc111bisisoquinolinebasedchiralligands |