Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

Phosphotyrosine-binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targets tyrosine-phosphorylated E-cadherin via an uncharacterized domain. In this study, the crystal structure of Hak...

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Bibliographic Details
Main Authors: Mukherjee, Manjeet, Chow, Soah Yee, Yusoff, Permeen, Seetharaman, J., Ng, Cherlyn, Sinniah, Saravanan, Koh, Xiao Woon, Asgar, Nur Farehan M., Li, Dan, Yim, Daniel, Jackson, Rebecca A., Yew, Jingxi, Qian, Jingru, Iyu, Audrey, Lim, Yoon Pin, Zhou, Xingding, Sze, Siu Kwan, Guy, Graeme R., Sivaraman, J.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/98086
http://hdl.handle.net/10220/13290

Internet

https://hdl.handle.net/10356/98086
http://hdl.handle.net/10220/13290

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