Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice

Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice

Antibodies are considered as ‘magic bullets’ because of their high specificity. It is believed that antibodies are too large to routinely enter the cytosol, thus antibody therapeutic approach has been limited to extracellular or secreted proteins expressed by cancer cells. However, many oncogenic pr...

Full description

Bibliographic Details
Main Authors: Guo, Ke, Tang, Jing Ping, Jie, Li, Hong, Cheng William, Tan, Cheng Peow Bobby, Park, Jung Eun, Varghese, Leyon, Feng, Zhiwei, Zhou, Jianbiao, Chng, Wee Joo, Zeng, Qi, Al-Aidaroos, Abdul Qader O.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/98490
http://hdl.handle.net/10220/10924
http://www.ncbi.nlm.nih.gov.ezlibproxy1.ntu.edu.sg/pmc/articles/PMC3326646/

Internet

https://hdl.handle.net/10356/98490
http://hdl.handle.net/10220/10924
http://www.ncbi.nlm.nih.gov.ezlibproxy1.ntu.edu.sg/pmc/articles/PMC3326646/

Similar Items