Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium Pictet-Spengler sequence
An efficient approach for the solid-phase synthesis of structurally diverse heterocyclic compounds is presented. Under acidic reaction conditions, peptidic levulinamides undergo intramolecular ketone–amide condensation reactions to form cyclic N-acyliminium intermediates. In the presence of a tether...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/99417 http://hdl.handle.net/10220/13003 |