| Summary: | Nifedipine is a cardiovascular drug with multiple use frequency within one
day for a long period of treatment. The absorption of nifedipine in gastric which
reaches 90% (Harjono, 2000) but has low dissolution which can cause the
decrease of bioavailability. Gastroretentive drug delivery system (GDDS) using
the effervescent is the right choice to ensure patient compliance and therapeutic
target.
The research aims to know the effect of HPMC K100M, ethylcellulose and
an effervescent component on the physical characteristics of the tablet mass (flow
rate, angle of repose, true density and compressibility) as well as the physical
characteristic of the tablet (hardness, friability, uniformity of content, absorption
potency, tablet size, floating lag time and dissolution test) as well as how the
composition of each factor to produce the optimum formula. Physical
characteristics of the test data were analyzed using the software Minitab 16
factorial design method. Determination of the mechanism of dissolution profiles
and curve fitting based on the cumulative weight of nifedipine is released.
Interpretation of dissolution profiles seen visually suitability models built from
zero-order approximation, first order, Higuchi and Michaelis-Menten against the
line of identity on the goodness of fit.
The results provide information was obtained that HPMC K100M affected
the decrease of floating lag time, DE360 and C360 significantly. Ethylcellulose
affered the increase of floating lag time and the decrease in the absorption potency
significantly. DE360 and C360 increased because of the significant effervescent
component effect. The optimum formula with HPMC K100M 64 mg,
ethylcelluloce 52 mg and effervescent component 33 mg gave the result of
floating lag time, absorption potency and C360 test which was not significantly
different on the minitab 16 prediction result. Curve fitting formed by first-order
approach is a model that correspond to the identity line, which means that the
release rate is influenced by the amount of nifedipine in tablets dominated
diffusion mechanism
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