| Summary: | Background. Synthetic hydroxyapatite is a kind of alloplastic material which
develops rapidly. The conventional synthetic hydroxyapatite with the most use is
the microcrystalline hydroxyapatite, which has a crystal structure measured in
micrometer. In the last decades, nanocrystalline hydroxyapatite (10-100 nm) has
considerably interested a number of researchers particularly on its physical,
mechanical, chemical and biological characteristics because it resembles the
natural hydroxyapatite in bone compared to the microcrystalline hydroxyapatite.
The study is aimed at finding out the comparison of the bone healing between the
nanocrystalline hydroxyapatite implantation and microcrystalline hydroxyapatite
implantation.
Method. The study is categorized into a pure experiment with 18 experimental
rabbits divided into 2 groups of decapitation periods i.e. 9 rabbits in the 2 -week
decapitation period and the rest 9 rabbits in the 4- week decapitation period. Each
of this decapitation period is further broken down into into 3 groups i.e. the group
of the nanocrystalline hydroxyapatite implantation, the group of the
microcrystalline hydroxyapatite implantation, and the control group.
Results. The nanocrystalline hydroxyapatite group demonstrates a significantly
higher new bone growth than the microcrystalline hydroxyapatite group within the
2-week period (p = 0,00). Likewise, the nanocrystalline hydroxyapatite group also
demonstrates a significantly higher new bone growth than the microcrystalline
hydroxyapatite within the 4-week period (p = 0.006)
Conclusion. The bone healing process in the nanocrystalline hydroxyapatite
implantation is faster than the one in the microcrystalline hydroxyapatite
implantation.
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