SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS
Eurycomanone is a C20 quassinoid found in pasak bumi roots plant (E. longifolia, Jack.) from family Simarubaceae. Five eurycomanone ester derivatives were synthesized by using starting material eurycomanone from pasak bumi roots and acetyl chloride, butiryl chloride, valeryl chloride, para-methoxybe...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1826047939067248640 |
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| author | , Hanifah Yusuf, Dra. Apt., M.Kes , Prof. Dr. Mustofa, M.Kes., Apt |
| author_facet | , Hanifah Yusuf, Dra. Apt., M.Kes , Prof. Dr. Mustofa, M.Kes., Apt |
| author_sort | , Hanifah Yusuf, Dra. Apt., M.Kes |
| collection | UGM |
| description | Eurycomanone is a C20 quassinoid found in pasak bumi roots plant (E. longifolia,
Jack.) from family Simarubaceae. Five eurycomanone ester derivatives were
synthesized by using starting material eurycomanone from pasak bumi roots and
acetyl chloride, butiryl chloride, valeryl chloride, para-methoxybenzoyl chloride
and succinic anhydride. The structure of semisynthesis products were determined
as eurycomanone triacetate, eurycomanone dibutyrate, eurycomanone
monovalerate, eurycomanone dimethoxybenzoate and eurycomanone disuccinate
based on their spectroscopic data of UV, IR, NMR and MS. These compounds
and eurycomanone itself were evaluated for their antiplasmodial activities against
3D7 chloroquine-sensitive strain of P. falciparum using Candle Jar method. Their
cytotoxic activities on Vero cells were assayed using MTT method and their
mechanism of action through inhibition of haem polymerization were also
determined by Bassilico et al. (1998) method. The antiplasmodial, cytotoxic, and
inhibition of haem polymerization activities were analyzed by linear regression
method for determining their IC50 values. The prediction for finding new
eurycomanone derivatives which are more potential, conducted through analysis
of quantitative structure-activity relationship (QSAR) using semiempirical
calculation with Austin Model-1 (AM1) method and the best equation gained by
multilinear regression analysis.
The result of antiplasmodial activity testing have been shown that eurycomanone
have IC50 value 0,0047 ± 0,0001 |
| first_indexed | 2024-03-13T23:19:15Z |
| format | Thesis |
| id | oai:generic.eprints.org:127997 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:19:15Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1279972016-03-04T07:57:02Z https://repository.ugm.ac.id/127997/ SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS , Hanifah Yusuf, Dra. Apt., M.Kes , Prof. Dr. Mustofa, M.Kes., Apt ETD Eurycomanone is a C20 quassinoid found in pasak bumi roots plant (E. longifolia, Jack.) from family Simarubaceae. Five eurycomanone ester derivatives were synthesized by using starting material eurycomanone from pasak bumi roots and acetyl chloride, butiryl chloride, valeryl chloride, para-methoxybenzoyl chloride and succinic anhydride. The structure of semisynthesis products were determined as eurycomanone triacetate, eurycomanone dibutyrate, eurycomanone monovalerate, eurycomanone dimethoxybenzoate and eurycomanone disuccinate based on their spectroscopic data of UV, IR, NMR and MS. These compounds and eurycomanone itself were evaluated for their antiplasmodial activities against 3D7 chloroquine-sensitive strain of P. falciparum using Candle Jar method. Their cytotoxic activities on Vero cells were assayed using MTT method and their mechanism of action through inhibition of haem polymerization were also determined by Bassilico et al. (1998) method. The antiplasmodial, cytotoxic, and inhibition of haem polymerization activities were analyzed by linear regression method for determining their IC50 values. The prediction for finding new eurycomanone derivatives which are more potential, conducted through analysis of quantitative structure-activity relationship (QSAR) using semiempirical calculation with Austin Model-1 (AM1) method and the best equation gained by multilinear regression analysis. The result of antiplasmodial activity testing have been shown that eurycomanone have IC50 value 0,0047 ± 0,0001 [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Hanifah Yusuf, Dra. Apt., M.Kes and , Prof. Dr. Mustofa, M.Kes., Apt (2014) SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68320 |
| spellingShingle | ETD , Hanifah Yusuf, Dra. Apt., M.Kes , Prof. Dr. Mustofa, M.Kes., Apt SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS |
| title | SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS |
| title_full | SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS |
| title_fullStr | SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS |
| title_full_unstemmed | SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS |
| title_short | SEMISINTESIS TURUNAN EURIKUMANON DARI EURIKUMANON AKAR PASAK BUMI (Eurycoma longifolia, Jack.), UJI AKTIVITAS ANTIPLASMODIUM DAN KAJIAN HUBUNGAN KUANTITATIF ANTARA STRUKTUR AKTIVITAS |
| title_sort | semisintesis turunan eurikumanon dari eurikumanon akar pasak bumi eurycoma longifolia jack uji aktivitas antiplasmodium dan kajian hubungan kuantitatif antara struktur aktivitas |
| topic | ETD |
| work_keys_str_mv | AT hanifahyusufdraaptmkes semisintesisturunaneurikumanondarieurikumanonakarpasakbumieurycomalongifoliajackujiaktivitasantiplasmodiumdankajianhubungankuantitatifantarastrukturaktivitas AT profdrmustofamkesapt semisintesisturunaneurikumanondarieurikumanonakarpasakbumieurycomalongifoliajackujiaktivitasantiplasmodiumdankajianhubungankuantitatifantarastrukturaktivitas |