Biosynthesis of A6'7-anhydroerythromycin via enoyl reductase inhibition by isonicotinic hydrazide (INH)
Isonicotinic hydrazide (INH) was added to a fermentation of mutant of Saccharopolyspora erythraea ATCC 11912 to inhibit the activity of 2,4,6,8-tetramethyI-7,9-dihydroxy-2-en-5-on-undecyl-ACP enoyl reductase, an enzyme which catalyses enoyl reduction process of an intermediate in the erythronolide b...
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[Yogyakarta] : Universitas Gadjah Mada
1999
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