| Summary: | High fat and high sugar diets in modern lifestyle can stimulate metabolic syndrome. This study aimed to evaluate the effect of goat milk kefir fermented with glucomannan from porang (Amorphophallus oncophillus) tuber on liver malondialdehyde (MDA) and histology and also peritoneal macrophage nitric oxide (NO) in metabolic syndrome rats. Male rats 8-12 weeks old were divided into 5 groups: (1) normal control, (2) metabolic syndrome control, (3) kefir, (4) kefir + porang glucomannan, and (5) simvastatin. To induce metabolic syndrome, the rats fed high fat and high fructose during 2 weeks, and then treated with kefir for 4 weeks (the rats continue received high fat and high fructose). The results showed that supplementation of goat milk kefir + porang glucomannan could decrease (p<0.01) MDA level in liver tissue of metabolic syndrome rats similar to the rats treated with simvastatin. The metabolic syndrome rats supplemented with kefir + porang glucomannan have more (p<0.01) NO in peritoneal macrophage than the normal rats, simvastatin and kefir groups. However, there were no significantly different in NO level between normal rats and rats with metabolic syndrome. Hepatocyte damage in group 1; 2; 3; 4 and 5 were 36.47%; 65.32%; 44.48%; 32.38%; 43.30%. Hepatic steatosis in group 1; 2; 3; 4 and 5 were 68.81%; 61.53%; 85.13%; 32.30%; 55.33%, respectively. In conclusion, supplementation of goat milk kefir fermented with porang glucomannan could improve the health through decreasing in hepatocyte abnormality, hepatic steatosis and MDA level and also increasing in NO level which potentially as an antimicrobial against intracellular pathogens in rats with metabolic syndrome.
Keywords: Goat milk kefir, Porang glucomannan, MDA, NO, Liver histology.
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