Physiologically-based pharmacokinetic model predictions of inter-ethnic differences in imatinib pharmacokinetics and dosing regimens

Physiologically-based pharmacokinetic model predictions of inter-ethnic differences in imatinib pharmacokinetics and dosing regimens

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Aims: This study implements a physiologically-based pharmacokinetic (PBPK) modelling approach to investigate inter-ethnic differences in imatinib pharmacokinetics and dosing regimens. Methods: A PBPK model of imatinib was built in the Simcyp Simulator (version 17) integrating in vitro drug metabolis...

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Bibliographic Details
Main Authors: Adiwidjaja, Jeffry, Gross, Annette S., Boddy, Alan V., McLachlan, Andrew J.
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
Pharmaceutical Sciences
Online Access:https://repository.ugm.ac.id/283054/1/Physiologically-based%20pharmacokinetic%20model%20predictions%20ofinter-ethnic%20differences%20in%20imatinib%20pharmacokinetics%20anddosing%20regimens.pdf

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https://repository.ugm.ac.id/283054/1/Physiologically-based%20pharmacokinetic%20model%20predictions%20ofinter-ethnic%20differences%20in%20imatinib%20pharmacokinetics%20anddosing%20regimens.pdf

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