Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method

Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method

Co-administered medicinal herbs can modify a drug’s pharmacokinetics (PK), effectiveness, and toxicity. Andrographis paniculata (Burm. f.) ethanolic extract (APE) and andrographolide (AND) (a potent CYP2C9 inducer/inhibitor) can alter the pharmacokinetic parameters of glipizide (GLZ). This study aim...

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Bibliographic Details
Main Authors: Sundhani, Elza, Nugroho, Agung Endro, Nurrochmad, Arief, Puspitasari, Ika, Amalia Prihati, Dita, Lukitaningsih, Endang
Format: Article
Language:English
Published: MDPI 2022
Subjects:
Pharmaceutical Sciences
Online Access:https://repository.ugm.ac.id/283613/1/46_Pharmacokinetic%20Herb-Drug%20Interactions%20of%20Glipizide%20with%20Andrographis%20paniculata%20%28Burm.%20f.%29%20and%20Andrographolide%20in%20Normal%20and%20Diabetic%20Rats%20by%20Validated%20HPLC%20Method.pdf

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https://repository.ugm.ac.id/283613/1/46_Pharmacokinetic%20Herb-Drug%20Interactions%20of%20Glipizide%20with%20Andrographis%20paniculata%20%28Burm.%20f.%29%20and%20Andrographolide%20in%20Normal%20and%20Diabetic%20Rats%20by%20Validated%20HPLC%20Method.pdf

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