Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery
Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation vari...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Informa Healthcare
2013
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| Online Access: | http://irep.iium.edu.my/31882/1/Microencapsulation_of_alpha_mangostin_J_Micro.pdf |
| _version_ | 1825647456101072896 |
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| author | Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah |
| author_facet | Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah |
| author_sort | Elsaid Ali, Aimen Abdo |
| collection | IIUM |
| description | Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs, optimized formula was 1% w/v polyvinyl alcohol, 1:10 ratio of oil to aqueous and sonicated at 2 and 5 min time for primary and secondary emulsion, respectively. Optimized responses for encapsulation efficiency, particle size and polydispersity index were found to be 39.12 ± 0.01%, 2.06 ± 0.017 µm and 0.95 ± 0.009, respectively, which matched values predicted by mathematical models. About 44.4% of the encapsulated alpha-mangostin was released over 4 weeks. Thermal analysis of the microspheres showed physical conversion of alpha-mangostin from crystallinity to amorphous with encapsulated one had lower in vitro cytotoxicity than free alpha-mangostin. Aerodynamic diameter (784.3 ± 7.5 nm) of this alpha-mangostin microsphere suggests suitability for peripheral pulmonary delivery.
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| first_indexed | 2024-03-05T23:17:53Z |
| format | Article |
| id | oai:generic.eprints.org:31882 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:17:53Z |
| publishDate | 2013 |
| publisher | Informa Healthcare |
| record_format | dspace |
| spelling | oai:generic.eprints.org:318822014-12-08T09:40:50Z http://irep.iium.edu.my/31882/ Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah RS Pharmacy and materia medica Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs, optimized formula was 1% w/v polyvinyl alcohol, 1:10 ratio of oil to aqueous and sonicated at 2 and 5 min time for primary and secondary emulsion, respectively. Optimized responses for encapsulation efficiency, particle size and polydispersity index were found to be 39.12 ± 0.01%, 2.06 ± 0.017 µm and 0.95 ± 0.009, respectively, which matched values predicted by mathematical models. About 44.4% of the encapsulated alpha-mangostin was released over 4 weeks. Thermal analysis of the microspheres showed physical conversion of alpha-mangostin from crystallinity to amorphous with encapsulated one had lower in vitro cytotoxicity than free alpha-mangostin. Aerodynamic diameter (784.3 ± 7.5 nm) of this alpha-mangostin microsphere suggests suitability for peripheral pulmonary delivery. Informa Healthcare 2013-04-30 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31882/1/Microencapsulation_of_alpha_mangostin_J_Micro.pdf Elsaid Ali, Aimen Abdo and Bakhtiar, M. Taher and Mohamed, Farahidah (2013) Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery. Journal of Microencapsulation. pp. 1-13. ISSN 1464-5246 (O), 0265-2048 (P) http://informahealthcare.com/doi/abs/10.3109/02652048.2013.788081 10.3109/02652048.2013.788081 |
| spellingShingle | RS Pharmacy and materia medica Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery |
| title | Microencapsulation of alpha-mangostin into PLGA microspheres
and optimization using response surface methodology intended
for pulmonary delivery |
| title_full | Microencapsulation of alpha-mangostin into PLGA microspheres
and optimization using response surface methodology intended
for pulmonary delivery |
| title_fullStr | Microencapsulation of alpha-mangostin into PLGA microspheres
and optimization using response surface methodology intended
for pulmonary delivery |
| title_full_unstemmed | Microencapsulation of alpha-mangostin into PLGA microspheres
and optimization using response surface methodology intended
for pulmonary delivery |
| title_short | Microencapsulation of alpha-mangostin into PLGA microspheres
and optimization using response surface methodology intended
for pulmonary delivery |
| title_sort | microencapsulation of alpha mangostin into plga microspheres and optimization using response surface methodology intended for pulmonary delivery |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/31882/1/Microencapsulation_of_alpha_mangostin_J_Micro.pdf |
| work_keys_str_mv | AT elsaidaliaimenabdo microencapsulationofalphamangostinintoplgamicrospheresandoptimizationusingresponsesurfacemethodologyintendedforpulmonarydelivery AT bakhtiarmtaher microencapsulationofalphamangostinintoplgamicrospheresandoptimizationusingresponsesurfacemethodologyintendedforpulmonarydelivery AT mohamedfarahidah microencapsulationofalphamangostinintoplgamicrospheresandoptimizationusingresponsesurfacemethodologyintendedforpulmonarydelivery |