Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surfa...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/36315/1/Published_paper.pdf |