Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro
Although 5-fluorouracil (5-FU) is a cornerstone of colorectal cancer (CRC) treatment, its efficacy is often limited by resistance. Wnt/β-catenin signalling plays a crucial role in CRC carcinogenesis and resistance, as Wnt expression is upregulated in 5-FU-resistant cells, protecting them from cell c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2025
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/10088/1/1-s2.0-S2405844025010874-main.pdf |