N-terminal Domain of Prion Protein Directs Its Oligomeric Association

N-terminal Domain of Prion Protein Directs Its Oligomeric Association

The self-association of prion protein (PrP) is a critical step in the pathology of prion diseases. It is increasingly recognized that small non-fibrillar β-sheet-rich oligomers of PrP may be of crucial importance in the prion disease process. Here, we characterize the structure of a well defined β-s...

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Bibliographic Details
Main Authors: Trevitt, Clare R., Hosszu, Laszlo L. P., Batchelor, Mark, Panico, Silvia, Terry, Cassandra, Nicoll, Andrew J., Risse, Emmanuel, Taylor, William A., Sandberg, Malin K., Al-Doujaily, Huda, Linehan, Jacqueline M., Saibil, Helen R., Scott, David J., Collinge, John, Waltho, Jonathan P., Clarke, Anthony R.
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
570 Life sciences; biology
Online Access:https://repository.londonmet.ac.uk/3844/1/zbc25497.pdf

Internet

https://repository.londonmet.ac.uk/3844/1/zbc25497.pdf

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