mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer's disease amyloid β-protein (Aβ). Non-NMDAR mechanisms remain relatively unexplored. Here we describe how Aβ facilitates NMDAR-independent long-t...

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Bibliographic Details
Main Authors: Hu, Neng-Wei, Nicoll, Andrew J., Zhang, Dainan, Mably, Alexandra J., O’Malley, Tiernan, Purro, Silvia A., Terry, Cassandra, Collinge, John, Walsh, Dominic M., Rowan, Michael J.
Format: Article
Language:English
Published: Nature Research 2014
Subjects:
570 Life sciences; biology
Online Access:https://repository.londonmet.ac.uk/3845/1/ncomms4374.pdf

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https://repository.londonmet.ac.uk/3845/1/ncomms4374.pdf

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