Peptidylarginine deiminase inhibitors reduce bacterial membrane vesicle release and sensitize bacteria to antibiotic treatment

Peptidylarginine deiminase inhibitors reduce bacterial membrane vesicle release and sensitize bacteria to antibiotic treatment

Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyze post-translational deimination/citrullination of p...

Full description

Bibliographic Details
Main Authors:	Kosgodage, Uchini S., Matewele, Paul, Mastroianni, Giulia, Kraev, Igor, Brotherton, Dominik, Awamaria, Brigitte, Nicholas, Anthony P., Lange, Sigrun, Inal, Jameel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019
Subjects:	570 Life sciences; biology
Online Access:	https://repository.londonmet.ac.uk/4974/1/fcimb-09-00227.pdf

Similar Items

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
by: Uchini S. Kosgodage, et al.
Published: (2019-06-01)

Peptidylarginine deiminases post-translationally deiminate prohibitin and modulate extracellular vesicle release and microRNAs in glioblastoma multiforme
by: Kosgodage, Uchini S., et al.
Published: (2018)

Cannabidiol Is a novel modulator of bacterial membrane vesicles
by: Kosgodage, Uchini S., et al.
Published: (2019)

A pilot study on peptidylarginine deiminases and protein deimination in animal cancers across vertebrate species
by: Inal, Jameel, et al.
Published: (2022)

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines
by: Uysal-Onganer, Pinar, et al.
Published: (2020)

Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells
by: Kosgodage, Uchini S., et al.
Published: (2018)

Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles
by: Uchini S. Kosgodage, et al.
Published: (2019-09-01)

Communication is key: extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants.
by: Stotz, Henrik U., et al.
Published: (2022)

A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species
by: Jameel M. Inal, et al.
Published: (2022-08-01)

Putative Roles for Peptidylarginine Deiminases in COVID-19
by: Elif Damla Arisan, et al.
Published: (2020-06-01)

Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair
by: Sigrun Lange
Published: (2021-01-01)

Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
by: Kosgodage, Uchini S.
Published: (2019)

A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release
by: Jorfi, Samireh, et al.
Published: (2023)

Membrane vesicles of clostridioides difficile and other clostridial species
by: Goh, Shan, et al.
Published: (2024)

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
by: Kholia, Sharadkumar Rajnikant, et al.
Published: (2015)

The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy
by: Moore, Colin, et al.
Published: (2017)

Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy
by: Inal, Jameel
Published: (2020)

In vivo expression of peptidylarginine deiminase in Drosophila melanogaster.
by: Olena Mahneva, et al.
Published: (2020-01-01)

Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis
by: M. Kristen Demoruelle, et al.
Published: (2021-06-01)

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets
by: Antwi-Baffour, Samuel, et al.
Published: (2019)

Porphyromonas gingivalis peptidylarginine deiminase in the aetiology of rheumatoid arthritis
by: Montgomery, AB
Published: (2016)

Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
by: Lin Wang, Xiaotian Chang, Guangying Yuan, Yan Zhao, Pengcheng Wang
Published: (2010-01-01)

Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions
by: Árni Kristmundsson, et al.
Published: (2021-02-01)

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures
by: Pinar Uysal-Onganer, et al.
Published: (2021-01-01)

Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases—Findings from a Pilot Study
by: Audrey Mercer, et al.
Published: (2022-10-01)

Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4
by: Ken Yoshida, et al.
Published: (2023-05-01)

Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis
by: Yudong Liu, et al.
Published: (2018-07-01)

Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase
by: Dres Damgaard, et al.
Published: (2017-01-01)

Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives
by: Zhenyu Wu, et al.
Published: (2021-11-01)

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4
by: Eva Guiducci, et al.
Published: (2018-07-01)

Identification and characterisation of the lactic acid bacteria associated with the traditional fermentation of dairy fermented product
by: Obioha, Promiselynda Ijeoma, et al.
Published: (2021)

Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells
by: Bruno Gavinho, et al.
Published: (2020-09-01)

Antimicrobial resistance of lactic acid bacteria from Nono, a naturally fermented milk product
by: Obioha, Promiselynda Ijeoma, et al.
Published: (2023)

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
by: Uchini S. Kosgodage, et al.
Published: (2019-03-01)

Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis
by: Christine Young, et al.
Published: (2022-06-01)

Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4).
by: Yi-Liang Liu, et al.
Published: (2011-01-01)

Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro
by: Evans-Osses, Ingrid, et al.
Published: (2017)

Technical challenges of working with extracellular vesicles
by: Ramirez, Marcel I., et al.
Published: (2017)

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis
by: Montgomery, AB, et al.
Published: (2015)

AUTODEIMINATION OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE: A NOVEL ANTIGEN IN RHEUMATOID ARTHRITIS
by: Lugli, E, et al.
Published: (2012)