The crystal structure of Mycobacterium tuberculosis Alkylhydroperoxidase AhpD, a potential target for antitubercular drug design
The resistance of Mycobacterium tuberculosis to isoniazid is commonly linked to inactivation of a catalase-peroxidase, KatG, that converts isoniazid to its biologically active form. Loss of KatG is associated with elevated expression of the alkylhydroperoxidases AhpC and AhpD. AhpD has no sequence i...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
2002
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