Regulation of HIF: prolyl hydroxylases.

Regulation of HIF: prolyl hydroxylases.

Hypoxia inducible factor (HIF) is an alpha/beta heterodimeric transcriptional complex that plays a key role in directing cellular responses to hypoxia. Recent studies have defined novel oxygen-sensitive signal pathways that regulate the activity of HIF by post-translational hydroxylation at specific...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Stolze, I, Mole, D, Ratcliffe, P
التنسيق:	Journal article
اللغة:	English
منشور في:	2006

مواد مشابهة

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
حسب: Mole, D, وآخرون
منشور في: (2003)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
حسب: Tuckerman, JR, وآخرون
منشور في: (2004)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
حسب: Schlemminger, I, وآخرون
منشور في: (2003)

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
حسب: Tian, Y, وآخرون
منشور في: (2006)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
حسب: Chan, M, وآخرون
منشور في: (2016)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
حسب: McNeill, L, وآخرون
منشور في: (2002)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
حسب: Masson, N, وآخرون
منشور في: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
حسب: Cockman, M, وآخرون
منشور في: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
حسب: Matthew E Cockman, وآخرون
منشور في: (2019-09-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
حسب: Chowdhury, R, وآخرون
منشور في: (2016)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
حسب: Yeoh, K, وآخرون
منشور في: (2013)

Iron homeostasis and its interaction with prolyl hydroxylases.
حسب: Mole, D
منشور في: (2010)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
حسب: Rasheduzzaman Chowdhury, وآخرون
منشور في: (2016-08-01)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
حسب: Yeh, TL, وآخرون
منشور في: (2017)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
حسب: Masson, N, وآخرون
منشور في: (2004)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
حسب: Chowdhury, R, وآخرون
منشور في: (2013)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
حسب: Andrey A. Poloznikov, وآخرون
منشور في: (2021-01-01)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
حسب: Wijeyekoon, JB
منشور في: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
حسب: Maria Savyuk, وآخرون
منشور في: (2020-07-01)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
حسب: Willam, C, وآخرون
منشور في: (2006)

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
حسب: Foxler, D, وآخرون
منشور في: (2012)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
حسب: Holt-Martyn, JP, وآخرون
منشور في: (2019)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
حسب: Lippl, K
منشور في: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
حسب: Takahiro Kambara, وآخرون
منشور في: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
حسب: Kiichi Hirota
منشور في: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
حسب: Kilian B. Kennel, وآخرون
منشور في: (2022-11-01)

Oxygen sensing by HIF hydroxylases.
حسب: Schofield, C, وآخرون
منشور في: (2004)

Signalling hypoxia by HIF hydroxylases.
حسب: Schofield, C, وآخرون
منشور في: (2005)

The HIF hydroxylase pathway and the tumour microenvironment
حسب: Ratcliffe, P
منشور في: (2008)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
حسب: Astuti, D, وآخرون
منشور في: (2011)

Prolyl hydroxylases and therapeutics.
حسب: Smith, T, وآخرون
منشور في: (2010)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
حسب: Chen, R, وآخرون
منشور في: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
حسب: Chen, R, وآخرون
منشور في: (2014)

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
حسب: Andrea Hartner, وآخرون
منشور في: (2023-06-01)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
حسب: Astuti, D, وآخرون
منشور في: (2010)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
حسب: Hewitson, K, وآخرون
منشور في: (2007)

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
حسب: Andrew N. Billin, وآخرون
منشور في: (2018-11-01)

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
حسب: Jaakkola, P, وآخرون
منشور في: (2001)

Substrate selectivity of prolyl hydroxylases
حسب: McDonough, M
منشور في: (2018)

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
حسب: Mayer, M, وآخرون
منشور في: (2018)