Regulation of HIF: prolyl hydroxylases.

Hypoxia inducible factor (HIF) is an alpha/beta heterodimeric transcriptional complex that plays a key role in directing cellular responses to hypoxia. Recent studies have defined novel oxygen-sensitive signal pathways that regulate the activity of HIF by post-translational hydroxylation at specific...

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Bibliographic Details
Main Authors: Stolze, I, Mole, D, Ratcliffe, P
Format: Journal article
Language:English
Published: 2006