A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

The glycan shield of human immunodeficiency virus type 1 (HIV-1) gp120 contributes to viral evasion from humoral immune responses. However, the shield is recognized by the HIV-1 broadly neutralizing antibody (Ab), 2G12, at a relatively conserved cluster of oligomannose glycans. The discovery of 2G12...

Повний опис

Бібліографічні деталі
Автори:	Astronomo, R, Lee, H, Scanlan, C, Pantophlet, R, Huang, C, Wilson, I, Blixt, O, Dwek, R, Wong, C, Burton, DR
Формат:	Journal article
Мова:	English
Опубліковано:	2008

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