Hypoxic microenvironment shapes HIV-1 replication and latency

Hypoxic microenvironment shapes HIV-1 replication and latency

Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary lymphoid tissues exist in a low-oxygen or hypo...

Full description

Bibliographic Details
Main Authors:	Zhuang, X, Pedroza-Pacheco, I, Nawroth, I, Kliszczak, AE, Magri, A, Paes, W, Rubio, CO, Yang, H, Ashcroft, M, Mole, D, Balfe, P, Borrow, P, McKeating, JA
Format:	Journal article
Language:	English
Published:	Nature Research 2020

Similar Items

Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency
by: Borrmann, H, et al.
Published: (2023)

Molecular components of the circadian clock regulate HIV-1 replication
by: Borrmann, H, et al.
Published: (2023)

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome
by: Tsukuda, S, et al.
Published: (2024)

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication
by: Borrmann, H, et al.
Published: (2020)

Oxygen-dependent histone lysine demethylase 4 restricts hepatitis B virus replication
by: Harris, JM, et al.
Published: (2024)

Molecular components of the circadian clock regulate HIV-1 replication
by: Helene Borrmann, et al.
Published: (2023-07-01)

Oxygen sensing and viral replication: implications for tropism and pathogenesis
by: Liu, PJ, et al.
Published: (2020)

Daytime variation in hepatitis C virus replication kinetics following liver transplant
by: Zhuang, X, et al.
Published: (2018)

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
by: Senko Tsukuda, et al.
Published: (2024-01-01)

Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo
by: Cardo, L, et al.
Published: (2018)

Oxygen Sensing and Viral Replication: Implications for Tropism and Pathogenesis
by: Peter Jianrui Liu, et al.
Published: (2020-10-01)

A PCR assay to quantify patterns of HBV transcription
by: D'Arienzo, V, et al.
Published: (2019)

The role of circadian clock pathways in viral replication
by: Zhuang, X, et al.
Published: (2022)

Daytime variation in hepatitis C virus replication kinetics following liver transplant [version 1; referees: 2 approved]
by: Xiaodong Zhuang, et al.
Published: (2018-08-01)

Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-art in vitro and mouse infection models
by: Liu, PJ, et al.
Published: (2020)

Daytime variation in hepatitis C virus replication kinetics following liver transplant [version 2; referees: 4 approved, 1 approved with reservations]
by: Xiaodong Zhuang, et al.
Published: (2018-09-01)

TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway
by: Fletcher, N, et al.
Published: (2017)

Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter
by: Wing, PAC, et al.
Published: (2021)

Circadian control of hepatitis B virus replication
by: Zhuang, X, et al.
Published: (2021)

Macrophages and the hypoxic tumour microenvironment.
by: Knowles, H, et al.
Published: (2007)

New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
by: Ward, C, et al.
Published: (2013)

New strategies for targeting the hypoxic tumour microenvironment in breast cancer
by: Ward, C, et al.
Published: (2013)

Impact of the hypoxic microenvironment on spermatogonial stem cells in culture
by: A. S. Gille, et al.
Published: (2024-01-01)

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.
by: Farquhar, M, et al.
Published: (2017)

The role of hypoxic microenvironment in autoimmune diseases
by: Xun Gong, et al.
Published: (2024-11-01)

Exosome-orchestrated hypoxic tumor microenvironment
by: Wanrong Meng, et al.
Published: (2019-03-01)

Tumour necrosis factors (alpha, beta) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication.
by: Vyakarnam, A, et al.
Published: (1990)

The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution
by: Ian M. Cartwright, et al.
Published: (2023-01-01)

The regulation of immune checkpoints by the hypoxic tumor microenvironment
by: Min Hu, et al.
Published: (2021-05-01)

RUNX Family in Hypoxic Microenvironment and Angiogenesis in Cancers
by: You Mie Lee
Published: (2022-10-01)

Microfluidic platform for the reproduction of hypoxic vascular microenvironments
by: Naoyuki Takahashi, et al.
Published: (2023-04-01)

Targeting hypoxic tumor microenvironment in pancreatic cancer
by: Jinxin Tao, et al.
Published: (2021-01-01)

Time-of-day variation in SARS-CoV-2 RNA levels during the second wave of COVID-19
by: Zhuang, X, et al.
Published: (2022)

Circadian control of hepatitis B virus replication
by: Xiaodong Zhuang, et al.
Published: (2021-03-01)

Hypoxic and pharmacological activation of HIFs inhibits SARS-CoV-2 infection of lung epithelial cells
by: Wing, P, et al.
Published: (2021)

Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
by: Zhou Chen, et al.
Published: (2023-02-01)

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
by: Zhuang, X, et al.
Published: (2019)

Read and write latency reduction in distributed objects with replication and caching
by: Toh, Hann Wei.
Published: (2008)

Sifting and Winnowing through Human Cytomegalovirus Lytic Replication and Latency.
by: Robert F Kalejta
Published: (2016-09-01)

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment
by: Yuyi Feng, et al.
Published: (2025-01-01)