MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants.

The ability of enterotoxin-based mucosal adjuvants to induce CD8+ MHC class I-restricted CTL responses to a codelivered bystander Ag was examined. Escherichia coli heat-labile toxin (LT), or derivatives of LT carrying mutations in the A subunit (LTR72, LTK63), were tested in parallel with cholera to...

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Bibliographic Details
Main Authors: Simmons, C, Mastroeni, P, Fowler, R, Ghaem-maghami, M, Lycke, N, Pizza, M, Rappuoli, R, Dougan, G
Format: Journal article
Language:English
Published: 1999