Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which genes modulate phenotypic variability, what their relationship i...

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Main Authors: Katsanos, D, Koneru, S, Mestek Boukhibar, L, Gritti, N, Ghose, R, Appleford, P, Doitsidou, M, Woollard, A, Van Zon, J, Poole, R, Barkoulas, M
格式: Journal article
语言:English
出版: Public Library of Science 2017