Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation. The hypoxia-inducible factor (HIF) oxygen-sensing pathway has a major effect on the susceptibility of neutrophils to apoptosis, with a marked...

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Bibliographic Details
Main Authors: Walmsley, SR, Chilvers, E, Thompson, A, Vaughan, K, Marriott, H, Parker, L, Shaw, G, Parmar, S, Schneider, M, Sabroe, I, Dockrell, D, Milo, M, Taylor, C, Johnson, R, Pugh, C, Ratcliffe, P, Maxwell, P, Carmeliet, P, Whyte, M
Format: Journal article
Language:English
Published: 2011

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