A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes

Regulatory interactions mediated by transcription factors (TFs) make up complex networks that control cellular behavior. Fully understanding these gene regulatory networks (GRNs) offers greater insight into the consequences of disease-causing perturbations than can be achieved by studying single TF...

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Bibliographic Details
Main Authors: Harman, JR, Thorne, R, Jamilly, M, Tapia, M, Crump, NT, Rice, S, Beveridge, R, Morrissey, E, de Bruijn, MFTR, Roberts, I, Roy, A, Fulga, TA, Milne, T
Format: Journal article
Language:English
Published: Cold Spring Harbor Laboratory Press 2021

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