Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Genetic variants affecting pancreatic islet enhancers are central to T2D risk, but the gene targets of islet enhancer activity are largely unknown. We generate a high-resolution map of islet chromatin loops using Hi-C assays in three islet samples and use loops to annotate target genes of islet enha...

Full description

Bibliographic Details
Main Authors: Greenwald, W, Chiou, J, Yan, J, Qiu, Y, Dai, N, Wang, A, Nariai, N, Aylward, A, Han, J, Kadakia, N, Regue, L, Okino, M, Drees, F, Kramer, D, Vinckier, N, Minichiello, L, Gorkin, D, Avruch, J, Frazer, K, Sander, M, Ren, B, Gaulton, K
Format: Journal article
Language:English
Published: Springer Nature 2019