A chemo-genomic approach identifies diverse epigenetic therapeutic vulnerabilities in MYCN-amplified neuroblastoma

Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role for epigenetic alterations in driving this cancer. While an increasing number of report...

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Bibliografski detalji
Glavni autori: Krstic, A, Konietzny, A, Halasz, M, Cain, P, Oppermann, U, Kolch, W, Duffy, DJ
Format: Journal article
Jezik:English
Izdano: Frontiers Media 2021