Cyclic Boronates Inhibit All Classes of β-Lactamase.

β-Lactamase-mediated resistance is a growing threat to the continued use of β-lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors clavulanic acid, sulbactam, tazobactam, and, more recently, the non-β-lactam inhibitor avibactam has extended the utility of β-lactams a...

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Bibliographic Details
Main Authors: Cahill, S, Cain, R, Wang, D, Lohans, C, Wareham, D, Oswin, H, Mohammed, J, Spencer, J, Fishwick, C, McDonough, M, Schofield, C, Brem, J
Format: Journal article
Language:English
Published: American Society for Microbiology 2017