Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via phosphorylation of downstream protein kinases - such as AMPK (AMP-activated protein kinase) and CAMK types I and IV. CAMKK2 relevance is hig...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Profeta, GS, Reis, CVD, Santiago, ADS, Godoi, PHC, Fala, AM, Wells, CI, Sartori, R, Salmazo, APT, Ramos, PZ, Massirer, KB, Elkins, JM, Drewry, DH, Gileadi, O, Couñago, RM
Μορφή: Journal article
Γλώσσα:English
Έκδοση: Springer Nature 2019

Παρόμοια τεκμήρια