Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.
Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via phosphorylation of downstream protein kinases - such as AMPK (AMP-activated protein kinase) and CAMK types I and IV. CAMKK2 relevance is hig...
Main Authors: | Profeta, GS, Reis, CVD, Santiago, ADS, Godoi, PHC, Fala, AM, Wells, CI, Sartori, R, Salmazo, APT, Ramos, PZ, Massirer, KB, Elkins, JM, Drewry, DH, Gileadi, O, Couñago, RM |
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Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2019
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