Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

BACKGROUND: HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) responses and the control of HIV-1, and it is unknown whether the size or distri...

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Bibliografiske detaljer
Main Authors:	Rolland, M, Heckerman, D, Deng, W, Rousseau, C, Coovadia, H, Bishop, K, Goulder, P, Walker, B, Brander, C, Mullins, J
Format:	Journal article
Sprog:	English
Udgivet:	2008

Lignende værker

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af: Yu, X, et al.
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Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
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Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
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Rare HLA drive additional HIV evolution compared to more frequent alleles.
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Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
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P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
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P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
af: Goulder PJ, et al.
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Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
af: Wright, J, et al.
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Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
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Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
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Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
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Immunodominance and viral ditness in Gag may contribute to differential viral control in HLA-B*7 supertype individuals acutely infected with HIV-1C
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HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques.
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Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.
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