Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

BACKGROUND: HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) responses and the control of HIV-1, and it is unknown whether the size or distri...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Rolland, M, Heckerman, D, Deng, W, Rousseau, C, Coovadia, H, Bishop, K, Goulder, P, Walker, B, Brander, C, Mullins, J
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	2008

Նմանատիպ նյութեր

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
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Հրապարակվել է: (2010)

HIV-1 Escape from an HLA-B*13-Restricted Gag Epitope Affects the Gag-Pol Frameshift Stem-loop and Reduces Viral Fitness
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Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
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Հրապարակվել է: (2008)

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics
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Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
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Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
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S04-06 OA. Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
‌: Julg, B, և այլն
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Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
‌: Yu, X, և այլն
Հրապարակվել է: (2002)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
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Հրապարակվել է: (2007)

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.
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Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells.
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Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
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P09-18. Cw 0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
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HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
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Հրապարակվել է: (2008)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restrieted gag epitope in chronic human immunodeficiency virus type 1 infection (vol 81, pg 8346, 2007)
‌: Crawford, H, և այլն
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Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+T cell activation and killing of virus infected cells
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HIV-1 subtype A gag variability and epitope evolution
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HIV-1 subtype A gag variability and epitope evolution.
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Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
‌: Wright, J, և այլն
Հրապարակվել է: (2009)

Rare HLA drive additional HIV evolution compared to more frequent alleles.
‌: Rousseau, C, և այլն
Հրապարակվել է: (2009)

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
‌: Matthews, P, և այլն
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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
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The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity
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Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques
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Population-specific evolution of HIV Gag epitopes in genetically diverged patients.
‌: Abidi, S, և այլն
Հրապարակվել է: (2013)

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
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Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
‌: Leslie, A, և այլն
Հրապարակվել է: (2010)

Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
‌: Addo, M, և այլն
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P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
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Հրապարակվել է: (2009)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
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Հրապարակվել է: (2009-10-01)

Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
‌: Wright, J, և այլն
Հրապարակվել է: (2012)

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
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Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes
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Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
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Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
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Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
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Revisiting the Influence of HLA-type, Frequency, HLA-supertype and Homozygosity on the Immune Control of HIV
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Immunodominance and viral ditness in Gag may contribute to differential viral control in HLA-B*7 supertype individuals acutely infected with HIV-1C
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HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques.
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Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.
‌: Matthews, P, և այլն
Հրապարակվել է: (2012)