Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

BACKGROUND: HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) responses and the control of HIV-1, and it is unknown whether the size or distri...

書誌詳細
主要な著者:	Rolland, M, Heckerman, D, Deng, W, Rousseau, C, Coovadia, H, Bishop, K, Goulder, P, Walker, B, Brander, C, Mullins, J
フォーマット:	Journal article
言語:	English
出版事項:	2008

類似資料

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
著者:: Rolland, M, 等
出版事項: (2010)

HIV-1 Escape from an HLA-B*13-Restricted Gag Epitope Affects the Gag-Pol Frameshift Stem-loop and Reduces Viral Fitness
著者:: Prado, J, 等
出版事項: (2008)

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
著者:: Carlson, J, 等
出版事項: (2008)

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics
著者:: Brander, Christian, 等
出版事項: (2011)

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
著者:: Honeyborne, I, 等
出版事項: (2007)

Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
著者:: Julg, B, 等
出版事項: (2009)

S04-06 OA. Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
著者:: Julg, B, 等
出版事項: (2009)

Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
著者:: Yu, X, 等
出版事項: (2002)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
著者:: Crawford, H, 等
出版事項: (2007)

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.
著者:: Goepfert, P, 等
出版事項: (2008)

Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells.
著者:: Kløverpris, H, 等
出版事項: (2013)

Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
著者:: Honeyborne, I, 等
出版事項: (2009)

P09-18. Cw 0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
著者:: Honeyborne, I, 等
出版事項: (2009)

Dendritic cells reveal a broad range of MHC class I epitopes for HIV-1 in persons with suppressed viral load on antiretroviral therapy.
著者:: Xiao-Li Huang, 等
出版事項: (2010-09-01)

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
著者:: Rousseau, C, 等
出版事項: (2008)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restrieted gag epitope in chronic human immunodeficiency virus type 1 infection (vol 81, pg 8346, 2007)
著者:: Crawford, H, 等
出版事項: (2008)

Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+T cell activation and killing of virus infected cells
著者:: Kloverpris, H, 等
出版事項: (2012)

Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
著者:: Wright, J, 等
出版事項: (2009)

HIV-1 subtype A gag variability and epitope evolution
著者:: Abidi, S, 等
出版事項: (2014)

HIV-1 subtype A gag variability and epitope evolution.
著者:: Syed Hani Abidi, 等
出版事項: (2014-01-01)

Rare HLA drive additional HIV evolution compared to more frequent alleles.
著者:: Rousseau, C, 等
出版事項: (2009)

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
著者:: Matthews, P, 等
出版事項: (2008)

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
著者:: Martinez-Picado, J, 等
出版事項: (2006)

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
著者:: Leslie, A, 等
出版事項: (2010)

The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity
著者:: Bastian Grewe, 等
出版事項: (2021-05-01)

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques
著者:: Xintao Hu, 等
出版事項: (2018-09-01)

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
著者:: Jonathan Hurtado, 等
出版事項: (2024-06-01)

Population-specific evolution of HIV Gag epitopes in genetically diverged patients.
著者:: Abidi, S, 等
出版事項: (2013)

Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
著者:: Addo, M, 等
出版事項: (2003)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
著者:: Wright, J, 等
出版事項: (2009)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
著者:: Goulder PJ, 等
出版事項: (2009-10-01)

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
著者:: Ngumbela, K, 等
出版事項: (2008)

Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
著者:: Wright, J, 等
出版事項: (2012)

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
著者:: Rousseau, C, 等
出版事項: (2007)

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
著者:: Wright, J, 等
出版事項: (2010)

Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
著者:: Julg, B, 等
出版事項: (2010)

Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes
著者:: Arnone Nithichanon, 等
出版事項: (2018-03-01)

Revisiting the Influence of HLA-type, Frequency, HLA-supertype and Homozygosity on the Immune Control of HIV
著者:: Leslie, A, 等
出版事項: (2008)

Immunodominance and viral ditness in Gag may contribute to differential viral control in HLA-B*7 supertype individuals acutely infected with HIV-1C
著者:: Gounder, K, 等
出版事項: (2012)

HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques.
著者:: Viraj Kulkarni, 等
出版事項: (2014-01-01)