ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and pr...

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Bibliographic Details
Main Authors: Sottocornola, R, Royer, C, Vives, V, Tordella, L, Zhong, S, Wang, Y, Ratnayaka, I, Shipman, M, Cheung, A, Gaston-Massuet, C, Ferretti, P, Molnár, Z, Lu, X
Format: Journal article
Language:English
Published: 2010

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