Defects in replicative DNA polymerases linked to cancer predisposition and tumour development
<p>Somatic and germline mutations in the exonuclease domain of the replicative DNA polymerase epsilon (POLE-EDM) can contribute to cancer development. The ultramutator phenotype observed in the POLE-EDM tumours is thought to be due to alteration of the polymerase proofreading ability. Notably,...
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| Format: | Thesis |
| Language: | English |
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2020
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