Interactions between a voltage sensor and a toxin via multiscale simulations.

Interactions between a voltage sensor and a toxin via multiscale simulations.

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Gating-modifier toxins inhibit voltage-gated ion channels by binding the voltage sensors (VS) and altering the energetics of voltage-dependent gating. These toxins are thought to gain access to the VS via the membrane (i.e., by partitioning from water into the membrane before binding the VS). We use...

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Bibliografiske detaljer
Main Authors:	Wee, C, Gavaghan, D, Sansom, MS
Format:	Journal article
Sprog:	English
Udgivet:	2010

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