Interactions between a voltage sensor and a toxin via multiscale simulations.

Gating-modifier toxins inhibit voltage-gated ion channels by binding the voltage sensors (VS) and altering the energetics of voltage-dependent gating. These toxins are thought to gain access to the VS via the membrane (i.e., by partitioning from water into the membrane before binding the VS). We use...

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書誌詳細
主要な著者: Wee, C, Gavaghan, D, Sansom, MS
フォーマット: Journal article
言語:English
出版事項: 2010

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