Interactions between a voltage sensor and a toxin via multiscale simulations.

Interactions between a voltage sensor and a toxin via multiscale simulations.

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Gating-modifier toxins inhibit voltage-gated ion channels by binding the voltage sensors (VS) and altering the energetics of voltage-dependent gating. These toxins are thought to gain access to the VS via the membrane (i.e., by partitioning from water into the membrane before binding the VS). We use...

Полное описание

Библиографические подробности
Главные авторы:	Wee, C, Gavaghan, D, Sansom, MS
Формат:	Journal article
Язык:	English
Опубликовано:	2010

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