Lipids shape the electron acceptor-binding site of the peripheral membrane protein dihydroorotate dehydrogenase
The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, a...
| Main Authors: | , , , , , , , , , , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
Cell Press
2018
|